This product is a P3HR-1 B cell engineering tool based on the Gold nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-huIgH296-SpCas9-L755507 ) genome editor.
| Host Cell | P3HR-1 |
| Target | CDH1 |
| Insert Clone | BCWJC-1781 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | DOX |
| Particle Size | <100 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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