This product is a GA-10 (Clone 4) B cell engineering tool based on the Magnetic nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | CDK2 |
| Insert Clone | 55/Cdk2 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-50 |
| Charge (mv) | ≤50 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
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