This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-321-huIgH296-Cas9-Nocodazole ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CDK5 |
| Insert Clone | EP715Y |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | 10-50 |
| Charge (mv) | 6 to 92 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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