This product is a Ramos (RA 1) B cell engineering tool based on the Microbubbles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CDKN2A |
| Insert Clone | BCWJC-1926 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Microbubbles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | DOX |
| Particle Size | ≤10000 |
| Charge (mv) | <-25 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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