This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-227-crispr RNA-SpCas9-SCR7 pyrazine ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CDKN2A |
| Insert Clone | FFWJF-5335 |
| Safe Harbor Sites (SHS) | SHS-227 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Regorafenib |
| Particle Size | 10-1000 |
| Charge (mv) | −8 to -55 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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