This product is a NCI-H929 [H929] B cell engineering tool based on the Nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | NCI-H929 [H929] |
| Target | EPHA1 |
| Insert Clone | BCGR-0964CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-8 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Talazoparib, temozolomide |
| Particle Size | 20-150 |
| Charge (mv) | -5 to -40 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Ovarian cancer |
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