This product is a U266B1 [U266] B cell engineering tool based on the Niosomes (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-317-huIgH296-Cas12-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | U266B1 [U266] |
| Target | FEN1 |
| Insert Clone | BCG-0495CR |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Niosomes |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Bortezomib |
| Particle Size | 10-500 |
| Charge (mv) | <80 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Lung cancer |
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