This product is a Ramos (RA 1) B cell engineering tool based on the Micelles (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-tracr RNA-SpCas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FEN1 |
| Insert Clone | BCG-2946CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Micelles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Celastrol |
| Particle Size | ≤900 |
| Charge (mv) | -2 to -30 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Lung cancer |
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