This product is a DG-75 [D.G.-75] B cell engineering tool based on the Quantum dots (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-RS-1 ) genome editor.
| Host Cell | DG-75 [D.G.-75] |
| Target | FLT1 |
| Insert Clone | 25F11 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Quantum dots |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | ESC8 |
| Particle Size | 20-150 |
| Charge (mv) | −2 to -30 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer; Colon cancer |
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