This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-289-crRNA:tracrRNA duplex-Cas12-Nocodazole ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FOLH1 |
| Insert Clone | 7F12 |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-1000 |
| Charge (mv) | 8-55 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.