This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | GHR |
| Insert Clone | BG-45F |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | DOX |
| Particle Size | 20-3000 |
| Charge (mv) | ≤50 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Lung cancer |
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