This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-Cas9-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | GPC3 |
| Insert Clone | BG-73F |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Dendrimers |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <500 |
| Charge (mv) | ≤50 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Non-small cell lung cancer; Prostate cancer; Liver cancer |
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