This product is a P3HR-1 B cell engineering tool based on the Solid lipid nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-crispr RNA-SpCas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | P3HR-1 |
| Target | IGF1R |
| Insert Clone | BG-4E |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 15-188 |
| Charge (mv) | <80 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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