This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (huROSA-26-huIgH296-Cas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | IGF1R |
| Insert Clone | BG-5E |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Dendrimers |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | Regorafenib |
| Particle Size | 10-1000 |
| Charge (mv) | -1 to -20 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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