This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (CCR5-sgRNA-Cpf1-Brefeldin A) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | IGF1R |
| Insert Clone | BG-6E |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <1000 |
| Charge (mv) | < 0.5 |
| Total Atom Count | -57,000,000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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