This product is a Raji-Luc2 B cell engineering tool based on the Gold nanoparticles (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-RS-1 ) genome editor.
| Host Cell | Raji-Luc2 |
| Target | IGF1R |
| Insert Clone | GFA5 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 1-100 |
| Charge (mv) | < 0 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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