This product is a Ramos (RA 1) B cell engineering tool based on the Microbubbles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (AAVS1-SpCas9-SpCas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | IL1R1 |
| Insert Clone | D0M4-130-46 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Microbubbles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Thymoquinone |
| Particle Size | <2500 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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