This product is a BC-1 B cell engineering tool based on the Nanoparticles (EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | BC-1 |
| Target | NASP |
| Insert Clone | A-8-CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 10-1000 |
| Charge (mv) | -15 to -185 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer |
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