This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (N-acetyl-D-glucosamine,sialic acid/Wheat germagglutinin) delivery system and CRISPR-based (SHS-323-SpCas9-Cas9-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NEK6 |
| Insert Clone | BCGW-1319CR |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | SpCas9 |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH-dependent |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | ESC8 |
| Particle Size | 20-2850 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Pancreatic cancer |
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