This product is a DG-75 [D.G.-75] B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-323-SpCas9-NLS-Cas9-L755507) genome editor.
| Host Cell | DG-75 [D.G.-75] |
| Target | SNAI1 |
| Insert Clone | BCGS-2257CR |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <500 |
| Charge (mv) | 10 to 30 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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