This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (SHS-323-huIgH296-Cas12-SCR7 pyrazine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | SRRM2 |
| Insert Clone | BCGS-2117CR |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | DOX |
| Particle Size | 20-150 |
| Charge (mv) | -3 to -71 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
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