This product is a BC-3 B cell engineering tool based on the Solid lipid nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-RS-1) genome editor.
| Host Cell | BC-3 |
| Target | STEAP1 |
| Insert Clone | M2I/92I.TQ |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 41-3500 |
| Charge (mv) | 11-91 |
| Total Atom Count | -55000000 |
| Surface Atoms (%) | -0.7 |
| Specific Surface Area (m2/g) | -3.6 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Colorectal cancer; Prostate cancer |
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