This product is a Toledo B cell engineering tool based on the Dendrimers (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-crispr RNA-SpCas9-RS-1) genome editor.
| Host Cell | Toledo |
| Target | VSIG1 |
| Insert Clone | BG-90C |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Dendrimers |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Thymoquinone |
| Particle Size | 15-188 |
| Charge (mv) | -29 to -80 |
| Total Atom Count | -64000000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Non-small cell lung cancer; Prostate cancer; Liver cancer; Ovarian cancer |
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