Human 4-1BB Ligand Matched Antibody Pair Set [ABP-P-322] (CAT#: ABP-P-322)

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The antibody pair set can be used to detect Human 4-1BB Ligand by sandwich ELISA. This antigen affinity purified capture antibody, combined with biotinylated detection antibody, allows for the detection of recombinant 4-1BB Ligand.

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Antigen Detail
Target4-1BB Ligand
DescriptionThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesMouse
ProductionAscite
CloneIV01646
IsotypeIgG
PurificationAffinity Chromatography
BufferA sterile filtered antibody solution was lyophilized from PBS, pH 7.2.
ApplicationELISA

Detection Antibody
Det-ClonalityPolyclonal
Host SpeciesRabbit
ProductionAntiserum
ConjugationBiotin
IsotypeIgG
PurificationAffinity Chromatography
ApplicationA sterile filtered antibody solution was lyophilized from PBS, pH 7.2.

General Product Property
Product OverviewThe antibody pair set can be used to detect Human 4-1BB Ligand by sandwich ELISA. This antigen affinity purified capture antibody, combined with biotinylated detection antibody, allows for the detection of recombinant 4-1BB Ligand.
SpecificityBoth the capture and the detection antibodies in this set react with Human 4-1BB Ligand.
Research AreaImmunology
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLiquid
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Plasma; Cell Culture Supernatant
Usage StatementAntibody is for research use only and not for use in diagnostic or therapeutic procedures.

Target Overview
Gene Symbol4-1BB Ligand
Full Nametumor necrosis factor (ligand) superfamily, member 9
BackgroundThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Alternative Names4-1BBL; 4-1BB ligand; Tumor necrosis factor ligand superfamily member 9; 4-1BB-L; CD137L;TNFSF9
Gene ID8744(Human)
Uniprot IDP41273(Human)

For Research Use Only.

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