Human ACP6 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-ACP6Detection Antibody: Mouse purified polyclonal anti-ACP6
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Antigen Detail | |
|---|---|
| Target | ACP6 |
| Description | Lysophosphatidic acid phosphatase type 6 is an acid phosphatase enzyme that is encoded in humans by the ACP6 gene. It acts as a phosphomonoesterase at low pHs. It is responsible for the hydrolysis of Lysophosphatidic acids (LPAs) to their respective monoacylglycerols and the release a free phosphate group in the process. The enzyme has higher activity for myristate-LPA (14 carbon chain), oleate-LPA (18 carbon chain and one unsaturated carbon-carbon bond), laurate-LPA (12 carbon chain) or palmitate-LPA (16 carbon chain). When the substrate is stearate-LPA (18 carbon chain), the enzyme has reduced activity. Phosphatidic acids can also be hydrolyzed by lysophosphatidic acid phosphatase, but at a significantly lower rate. The addition of the second fatty chain makes fitting into the active site much harder. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ACP6 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-ACP6 Detection Antibody: Mouse purified polyclonal anti-ACP6 |
| Specificity | Validated for detecting natural and recombinant human ACP6 |
| Research Area | Metabolism |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ACP6 |
| Full Name | Lysophosphatidic acid phosphatase type 6 |
| Background | This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016] |
| Alternative Names | ACPL1; LPAP; PACPL1; acid phosphatase 6; lysophosphatidic |
| Gene ID | 51205 |
| Uniprot ID | Q9NPH0 |
| GeneCards | ACP6 |
| HGNC | 29609 |
| Ensembl | ENSG00000162836 |
| OMIM | 611471 |
| Involvement in Disease | Diseases associated with ACP6 include Cerebral Visual Impairment and Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb. |
| Function | Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. |
| Related Pathways | Its related pathways are Metabolism and Glycerophospholipid biosynthesis. |
For Research Use Only.
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