Human ACTL7B Matched Antibody Pair set for ELISA use
Capture Antibody: Rabbit purified polyclonal anti-ACTL7B
Detection Antibody: Mouse monoclonal anti-ACTL7B, IgG2a Kappa
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Antigen Detail | |
|---|---|
| Target | ACTL7B |
| Description | The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD1014 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ACTL7B Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-ACTL7B Detection Antibody: Mouse monoclonal anti-ACTL7B, IgG2a Kappa |
| Specificity | Validated for detecting natural and recombinant human ACTL7B |
| Research Area | Binding; Subcellular location |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ACTL7B |
| Full Name | Actin Like 7B |
| Background | The protein is a member of a family of actin-related proteins (ARPs). The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. |
| Alternative Names | Actin Like 7B; Actin-Like Protein 7B; Testis Tissue Sperm-Binding Protein Li 43a; Actin-Like-7-Beta; ACTL7B |
| Gene ID | 10880 |
| Uniprot ID | Q9Y614 |
| HGNC | 162 |
| Ensembl | ENSG00000148156 |
| OMIM | 604304 |
| Involvement in Disease | Diseases associated with ACTL7B include Dysautonomia and Hypertensive Nephropathy. |
| Function | ACTL7B (Actin Like 7B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural constituent of cytoskeleton. |
For Research Use Only.