Human APOA1 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-APOA1Detection Antibody: Mouse purified polyclonal anti-APOA1
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Antigen Detail | |
|---|---|
| Target | APOA1 |
| Description | Apolipoprotein A1 is a protein that in humans is encoded by the APOA1 gene. It has a specific role in lipid metabolism. The text in a 2014 report suggested that APOA1 mRNA is regulated by endogenously expressed antisense RNA. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human APOA1 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-APOA1 Detection Antibody: Mouse purified polyclonal anti-APOA1 |
| Specificity | Validated for detecting natural and recombinant human APOA1 |
| Research Area | Lipids |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | APOA1 |
| Full Name | Apolipoprotein A1 |
| Background | Apurinic/apyrimidinic (AP) sites (also called "abasic sites") occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication. All cells, from simple prokaryotes to humans, have evolved systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site, thereby initiating a process known as?base excision repair?(BER). The APEX gene (alternatively named APE1, HAP1, APEN) encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. |
| Alternative Names | APOA1; entrez:335; apo(a); apolipoprotein A1; Apolipoprotein A-I; HPALP2 |
| Gene ID | 335 |
| Uniprot ID | P02647 |
| GeneCards | APOA1 |
| HGNC | 600 |
| Ensembl | ENSG00000118137 |
| OMIM | 107680 |
| Involvement in Disease | Diseases associated with APOA1 include Hypoalphalipoproteinemia, Primary, 2 and Amyloidosis, Familial Visceral. |
| Function | The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. |
| Related Pathways | Its related pathways are Lipoprotein metabolism and Folate Metabolism. |
For Research Use Only.
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