Human ARHGDIB Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-ARHGDIBDetection Antibody: Mouse purified polyclonal anti-ARHGDIB
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Antigen Detail | |
|---|---|
| Target | ARHGDIB |
| Description | Rho GDP-dissociation inhibitor 2 is a protein that in humans is encoded by the ARHGDIB gene. Aliases of this gene include RhoGDI2, GDID4, Rho GDI 2, and others.The ARHGDIB is a lymphoid-specific intrinsic negative regulator of HIV-1 replication that acts by simultaneously inhibiting RhoA and Rac1 functions. Results suggest that D4-GDI may function as a biphasic regulator of breast cancer progression and metastasis. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ARHGDIB Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-ARHGDIB Detection Antibody: Mouse purified polyclonal anti-ARHGDIB |
| Specificity | Validated for detecting natural and recombinant human ARHGDIB |
| Research Area | Focal Adhesions |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ARHGDIB |
| Full Name | Rho GDP Dissociation Inhibitor Beta |
| Background | Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]). |
| Alternative Names | Ly-GDI; Rho GDI 2 |
| Gene ID | 397 |
| Uniprot ID | P52566 |
| GeneCards | ARHGDIB |
| HGNC | 679 |
| Ensembl | ENSG00000111348 |
| OMIM | 602843 |
| Related Pathways | Its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. |
For Research Use Only.
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