Human ASB9 Matched Antibody Pair set for ELISA use
Capture Antibody: Rabbit purified polyclonal anti-ASB9
Detection Antibody: Mouse monoclonal anti-ASB9, IgG1 Kappa
(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Antigen Detail | |
|---|---|
| Target | ASB9 |
| Description | ASB-9, ankyrin repeat and suppressor of cytokine signaling box protein 9, binds to creatine kinase (CK) and targets it for degradation |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD10176 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ASB9 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-ASB9 Detection Antibody: Mouse monoclonal anti-ASB9, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human ASB9 |
| Research Area | Proteolysis/Ubiquitin |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ASB9 |
| Full Name | Ankyrin Repeat And SOCS Box Containing 9 |
| Background | This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] |
| Alternative Names | Ankyrin Repeat And SOCS Box Protein 9; Testis Tissue Sperm-Binding Protein Li 57p |
| Gene ID | 140462 |
| Uniprot ID | Q96DX5 |
| HGNC | 17184 |
| Ensembl | ENSG00000102048 |
| OMIM | 300890 |
| Involvement in Disease | Diseases associated with ASB9 include Uterine Corpus Endometrial Carcinoma. |
| Function | Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. |
| Related Pathways | Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. |
For Research Use Only.