Human ATGL antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | ATGL |
| Description | Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene.[5][6][7][8][excessive citations] ATGL catalyses the first reaction of lipolysis,[9] where triacylglycerols are hydrolysed to diacylglycerols. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01693 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD1031 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Human ATGL antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Human ATGL . |
| Range | 218.75 pg/mL-14000 pg/mL |
| Research Area | Neuroscience; Signal Transduction; Metabolism |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | PNPLA2 |
| Full Name | Adipose triglyceride lipase |
| Background | Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene.[5][6][7][8][excessive citations] ATGL catalyses the first reaction of lipolysis,[9] where triacylglycerols are hydrolysed to diacylglycerols. |
| Alternative Names | PNPLA2; 1110001C14Rik; ATGL; PEDF-R; TTS-2.2; TTS2; iPLA2zeta; FP17548; patatin like phospholipase domain containing 2 |
| Gene ID | 57104 |
| Uniprot ID | Q96AD5 |
| GeneCards | PNPLA2 |
| HGNC | 30802 |
| Ensembl | ENSG00000177666 |
| OMIM | 609059 |
| Involvement in Disease | Diseases associated with PNPLA2 include Neutral Lipid Storage Disease With Myopathy and Triglyceride Deposit Cardiomyovasculopathy. |
| Function | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674, PubMed:15364929, PubMed:16150821). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone (By similarity). Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade. |
For Research Use Only.
Application