Human BAIAP2 Matched Antibody Pair set for ELISA use
Capture Antibody: Mouse monoclonal anti-BAIAP2
Detection Antibody: Rabbit purified polyclonal anti-BAIAP2
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Antigen Detail | |
|---|---|
| Target | BAIAP2 |
| Description | Brain-specific angiogenesis inhibitor 1-associated protein 2 is a protein that in humans is encoded by the BAIAP2 gene. BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01825 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human BAIAP2 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-BAIAP2 Detection Antibody: Rabbit purified polyclonal anti-BAIAP2 |
| Specificity | Validated for detecting natural and recombinant human BAIAP2 |
| Research Area | Cytoskeleton |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | BAIAP2 |
| Full Name | BAR/IMD Domain Containing Adaptor Protein 2 |
| Background | The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009] |
| Alternative Names | Fas Ligand-Associated Factor 3; WASP And MIM Like; IRS-58 |
| Gene ID | 10458 |
| Uniprot ID | Q9UQB8 |
| GeneCards | BAIAP2 |
| HGNC | 947 |
| Ensembl | ENSG00000175866 |
| OMIM | 605475 |
| Involvement in Disease | Diseases associated with BAIAP2 include Dentatorubral-Pallidoluysian Atrophy and Wiskott-Aldrich Syndrome. |
| Function | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. |
| Related Pathways | Its related pathways are Signaling by GPCR and G-protein signaling RAC1 in cellular process. |
For Research Use Only.