Human BIRC5 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-BIRC5Detection Antibody: Mouse monoclonal anti-BIRC5, IgG2a Kappa
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Antigen Detail | |
|---|---|
| Target | BIRC5 |
| Description | BIRC5 is a protein in the intrinsic apoptotic pathway that interacts with XIAP and DIABLO leading to caspase-3 and caspase-9 inactivation. BIRC5 is also involved in stabilizing the microtubule-kinetochore dynamics. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD10301 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human BIRC5 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-BIRC5 Detection Antibody: Mouse monoclonal anti-BIRC5, IgG2a Kappa |
| Specificity | Validated for detecting natural and recombinant human BIRC5 |
| Research Area | Apoptosis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | BIRC5 |
| Full Name | Baculoviral IAP repeat-containing 5 |
| Background | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| Alternative Names | BIRC5; Baculoviral IAP repeat-containing 5 |
| Gene ID | 332 |
| Uniprot ID | O15392 |
| GeneCards | BIRC5 |
| HGNC | HGNC(593) |
| Ensembl | Ensembl(ENSG00000089685) |
| OMIM | OMIM(603352) |
| Involvement in Disease | Diseases associated with BIRC5 include Adenocarcinoma and Cervical Intraepithelial Neoplasia. |
| Function | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. |
| Related Pathways | Its related pathways are Apoptosis Modulation and Signaling and Interleukin-11 Signaling Pathway. |
For Research Use Only.
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