Human C7 ELISA Matched Antibody Pair Set [ABP-Q-04-45] (CAT#: ABP-Q-04-45)

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Human C7 antibody pair set for ELISA use
Capture Antibody: rabbit anti-Human C7 monoclonal antibody
Detection Antibody: rabbit anti-Human C7 polyclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $1,120.00
Antibody Pair Set-Package 2 15 × 96 tests $2,331.43
Datasheet
MSDS
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Lot Number

Antigen Detail
TargetC7
DescriptionComplement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesRabbit
CloneIV01477
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityPolyclonal
Host SpeciesRabbit
ConjugationHRP
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewHuman C7 antibody pair set for ELISA use
Capture Antibody: rabbit anti-Human C7 monoclonal antibody
Detection Antibody: rabbit anti-Human C7 polyclonal antibody conjugated to HRP
SpecificityQuantitative determination of Human C7
Range31.25-2000 pg/mL
Research AreaInnate Immunity
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolC7
Full NameComplement C7
BackgroundThis gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.
Alternative NamesComplement Component 7
Gene ID730
Uniprot IDP10643

For Research Use Only.

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