Human CBY1 Matched Antibody Pair set for ELISA use
Capture Antibody: Rabbit purified polyclonal anti-CBY1
Detection Antibody: Mouse monoclonal anti-CBY1, IgG1 Kappa
(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Antigen Detail | |
|---|---|
| Target | CBY1 |
| Description | Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD1087 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CBY1 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-CBY1 Detection Antibody: Mouse monoclonal anti-CBY1, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human CBY1 |
| Research Area | Transcriptional activator |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CBY1 |
| Full Name | Chibby Family Member 1, Beta Catenin Antagonist |
| Background | Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. |
| Alternative Names | C22orf2; CBY; HS508I15A; PGEA1; PIGEA-14; PIGEA14; arb1; chibby homolog 1 (Drosophila); chibby family member 1; |
| Gene ID | 25776 |
| Uniprot ID | Q9Y3M2 |
| GeneCards | CBY1 |
| HGNC | 1307 |
| Ensembl | ENSG00000100211 |
| OMIM | 607757 |
| Involvement in Disease | Diseases associated with CBY1 include Ulcerative Blepharitis and Pediatric Ependymoma. |
| Function | Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. |
| Related Pathways | Its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Signaling by GPCR. |
For Research Use Only.