Anti-CD40L Antibody Pair Set Capture Antibody: Mouse Monoclonal IgGDetection Antibody: Mouse Monoclonal IgG1-Unconjugated
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Antigen Detail | |
|---|---|
| Target | CD40L |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Immunogen | CD40L antibody was raised in mouse using recombinant human soluble CD40 Ligand / TRAP Analog as the immunogen. |
| Clone | IV0127 |
| Isotype | IgG1 |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Immunogen | CD40L antibody was raised in mouse using recombinant human soluble CD40 Ligand / TRAP Analog as the immunogen. |
| Conjugation | Unconjugated |
| Clone | RD10221 |
| Isotype | IgG1 |
| Purification | Protein A |
| Application | PBS, pH 7.4, 0.1 % NaN3. |
General Product Property | |
|---|---|
| Product Overview | Anti-CD40L Antibody Pair Set Capture Antibody: Mouse Monoclonal IgG Detection Antibody: Mouse Monoclonal IgG1-Unconjugated |
| Specificity | The specificity of capture antibody: Human sCD40L The specificity of detection antibody: Human sCD40L |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 set |
| Sample Type | Serum; Plasma; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CD40LG |
| Full Name | Cluster of differentiation 154 |
| Background | CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation, an important process in the adaptive immune system. |
| Alternative Names | CD40LG; CD154; CD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP; gp39; hCD40L; CD40 ligand |
| Gene ID | 959 (Human); 21947 (Mouse) |
| Uniprot ID | P22965 (Human); P27548 (Mouse) |
For Research Use Only.
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