Human CHML Matched Antibody Pair set for ELISA use
Capture Antibody: Mouse monoclonal anti-CHML
Detection Antibody: Rabbit purified polyclonal anti-CHML
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Antigen Detail | |
|---|---|
| Target | CHML |
| Description | Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01993 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CHML Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-CHML Detection Antibody: Rabbit purified polyclonal anti-CHML |
| Specificity | Validated for detecting natural and recombinant human CHML |
| Research Area | Neurotransmission |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CHML |
| Full Name | CHM Like Rab Escort Protein |
| Background | The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. |
| Alternative Names | Rab Proteins Geranylgeranyltransferase Component A 2; REP-2; REP2; Choroideraemia-Like Protein; CHM Like Rab Escort Protein 2 |
| Gene ID | 1122 |
| Uniprot ID | P26374 |
| GeneCards | CHML |
| HGNC | 1941 |
| Ensembl | ENSG00000203668 |
| OMIM | 118825 |
| Involvement in Disease | Diseases associated with CHML include Choroideremia and Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema. |
| Function | Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. |
| Related Pathways | Its related pathways are RAB GEFs exchange GTP for GDP on RABs and Metabolism of proteins. |
For Research Use Only.