Human CREB3 Matched Antibody Pair set for ELISA use
Capture Antibody: Mouse monoclonal anti-CREB3
Detection Antibody: Rabbit purified polyclonal anti-CREB3
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Antigen Detail | |
|---|---|
| Target | CREB3 |
| Description | Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene. It is a transcription factors activated upon intramembrane proteolysis (RIP), binds the cAMP response element (CRE) (consensus: 5'-GTGACGT [AG] [AG]-3'), a sequence present in many viral and cellular promoters. CREB3 binds to and requires HCFC1 as a coactivator. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01257 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CREB3 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-CREB3 Detection Antibody: Rabbit purified polyclonal anti-CREB3 |
| Specificity | Validated for detecting natural and recombinant human CREB3 |
| Research Area | Host Virus Interaction |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CREB3 |
| Full Name | CAMP Responsive Element Binding Protein 3 |
| Background | This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009] |
| Alternative Names | SLZIP; Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1 |
| Gene ID | 10488 |
| Uniprot ID | O43889 |
| GeneCards | CREB3 |
| HGNC | 2347 |
| Ensembl | ENSG00000107175 |
| OMIM | 606443 |
| Involvement in Disease | Diseases associated with CREB3 include Herpes Simplex and T-Cell Lymphoblastic Leukemia/Lymphoma. |
| Function | Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613). |
| Related Pathways | Its related pathways are ATM Pathway and NGF Pathway. |
For Research Use Only.