Human CREM Matched Antibody Pair set for ELISA use
Capture Antibody: Rabbit affinity purified polyclonal anti-CREM
Detection Antibody: Mouse polyclonal anti-CREM
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Antigen Detail | |
|---|---|
| Target | CREM |
| Description | cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. It has multiple isoforms, which act either as repressors or activators. CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals. CREM transcription factors also play an important role in many physiological systems, such as cardiac function, circadian rhythms, locomotion and spermatogenesis. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CREM Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit affinity purified polyclonal anti-CREM Detection Antibody: Mouse polyclonal anti-CREM |
| Specificity | Validated for detecting natural and recombinant human CREM |
| Research Area | Nucleotide Messenger |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CREM |
| Full Name | CAMP Responsive Element Modulator |
| Background | This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] |
| Alternative Names | HCREM-2; ICER; CREM-2 |
| Gene ID | 1390 |
| Uniprot ID | Q03060 |
| GeneCards | CREM |
| HGNC | 2352 |
| Ensembl | ENSG00000095794 |
| OMIM | 123812 |
| Involvement in Disease | Diseases associated with CREM include Male Infertility and Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency. |
| Function | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). |
| Related Pathways | Its related pathways are Activation of cAMP-Dependent PKA and Transcription_CREM signaling in testis. |
For Research Use Only.