Human CRYGD Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-CRYGDDetection Antibody: Mouse purified polyclonal anti-CRYGD
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Antigen Detail | |
|---|---|
| Target | CRYGD |
| Description | Gamma-crystallin D is a protein that in humans is encoded by the CRYGD gene. CRYGD is a member of the beta/gamma-crystallin family. Crystallins are the principal structural components of the vertebrate eye lens. The mammalian lens crystallins are divided into alpha, beta, and gamma families. Gamma-crystallins are involved in cataract formation. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CRYGD Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-CRYGD Detection Antibody: Mouse purified polyclonal anti-CRYGD |
| Specificity | Validated for detecting natural and recombinant human CRYGD |
| Research Area | Sensory System |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CRYGD |
| Full Name | Crystallin Gamma D |
| Background | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008] |
| Alternative Names | CCP; PCC; CACA; CCA3; CRYG4; CTRCT4; cry-g-D |
| Gene ID | 1421 |
| Uniprot ID | P07320 |
| GeneCards | CRYGD |
| HGNC | 2411 |
| Ensembl | 123690 |
| OMIM | 123690 |
| Involvement in Disease | Diseases associated with CRYGD include Cataract 4, Multiple Types and Cataract 29. |
| Function | Crystallins are the dominant structural components of the vertebrate eye lens. |
For Research Use Only.
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