Human CSE1L Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-CSE1L, IgG1 KappaDetection Antibody: Mouse monoclonal anti-CSE1L, IgG1 Kappa
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Antigen Detail | |
|---|---|
| Target | CSE1L |
| Description | CSE1L (CSE1 chromosome segregation 1-like (yeast)) is a protein-coding gene. CSE1L participates in regulating cell mitosis in human seminoma. CSE1L has been reported to be highly expressed in various tumours. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01978 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Biotin |
| Clone | RD10325 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CSE1L Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-CSE1L, IgG1 Kappa Detection Antibody: Mouse monoclonal anti-CSE1L, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human CSE1L |
| Research Area | Apoptosis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CSE1L |
| Full Name | Chromosome Segregation 1 Like |
| Background | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] |
| Alternative Names | CAS; XPO2; Exp2 |
| Gene ID | 1434 |
| Uniprot ID | P55060 |
| HGNC | 2431 |
| Ensembl | ENSG00000124207 |
| OMIM | 601342 |
| Involvement in Disease | Diseases associated with CSE1L include Speech Disorder and Colorectal Cancer. |
| Function | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Related Pathways | Its related pathways are Cell cycle_Spindle assembly and chromosome separation and Direct p53 effectors. |
For Research Use Only.
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