Human CTGF Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-CTGF, IgG2b KappaDetection Antibody: Mouse monoclonal anti-CTGF, IgG2b Kappa
Specific Inquiry(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Antigen Detail | |
|---|---|
| Target | CTGF |
| Description | CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01702 |
| Isotype | IgG2b, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Biotin |
| Clone | RD10368 |
| Isotype | IgG2b, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human CTGF Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-CTGF, IgG2b Kappa Detection Antibody: Mouse monoclonal anti-CTGF, IgG2b Kappa |
| Specificity | Validated for detecting natural and recombinant human CTGF |
| Research Area | Angiogenesis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CCN2 |
| Full Name | Cellular Communication Network Factor 2 |
| Background | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009] |
| Alternative Names | CTGF; NOV2; HCS24; IGFBP8 |
| Gene ID | 1490 |
| Uniprot ID | P29279 |
| HGNC | 2500 |
| Ensembl | ENSG00000118523 |
| OMIM | 121009 |
| Involvement in Disease | Diseases associated with CCN2 include Renal Fibrosis and Systemic Scleroderma. |
| Function | Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. |
| Related Pathways | Its related pathways are NF-KappaB Family Pathway and amb2 Integrin signaling. |
For Research Use Only.
Related products