Human DCTN2 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-DCTN2Detection Antibody: Mouse polyclonal anti-DCTN2
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Antigen Detail | |
|---|---|
| Target | DCTN2 |
| Description | Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene. DCTN2 is a 50 kDa intracellular member of the Dynactin family of phosphoproteins. It is ubiquitously expressed and serves to stabilize the Dynactin complex of 11 different proteins. This complex is an obligate cofactor of Dynein and Kinesin motors, which position the mitotic spindle for cell division and move vesicles within the cell. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DCTN2 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-DCTN2 Detection Antibody: Mouse polyclonal anti-DCTN2 |
| Specificity | Validated for detecting natural and recombinant human DCTN2 |
| Research Area | Cell Cycle |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DCTN2 |
| Full Name | Dynactin Subunit 2 |
| Background | This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Alternative Names | 50 KDa Dynein-Associated Polypeptide; Epididymis Secretory Sperm Binding Protein; Dynactin Complex 50 KDa Subunit; P50 Dynamitin |
| Gene ID | 10540 |
| Uniprot ID | Q13561 |
| GeneCards | DCTN2 |
| HGNC | 2712 |
| Ensembl | ENSG00000175203 |
| OMIM | 607376 |
| Involvement in Disease | Diseases associated with DCTN2 include Charcot-Marie-Tooth Disease and Neuronopathy, Distal Hereditary Motor, Type Viib. |
| Function | Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. |
| Related Pathways | Its related pathways are Cell cycle_Spindle assembly and chromosome separation and Organelle biogenesis and maintenance. |
For Research Use Only.
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