Human DDC Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-DDCDetection Antibody: Mouse polyclonal anti-DDC
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Antigen Detail | |
|---|---|
| Target | DDC |
| Description | Dopa Decarboxylase (DDC), also known as aromatic amino acid decarboxylase, is a group II decarboxylase. The enzyme catalyzes the decarboxylation of aromatic L-amino acids to produce the corresponding amines. DDC produces the neurotransmitters dopamine and serotonin from L-Dopa and L-5-hydroxytryptophan, respectively. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DDC Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-DDC Detection Antibody: Mouse polyclonal anti-DDC |
| Specificity | Validated for detecting natural and recombinant human DDC |
| Research Area | Neurotransmission |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DDC |
| Full Name | Dopa Decarboxylase |
| Background | The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
| Alternative Names | Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) |
| Gene ID | 1644 |
| Uniprot ID | P20711 |
| HGNC | 2719 |
| Ensembl | ENSG00000132437 |
| OMIM | 107930 |
| Involvement in Disease | Diseases associated with DDC include Aromatic L-Amino Acid Decarboxylase Deficiency and Dopamine Beta-Hydroxylase Deficiency. |
| Function | Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. |
| Related Pathways | Its related pathways are Neuroscience and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. |
For Research Use Only.
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