Human DLX1 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-DLX1Detection Antibody: Rabbit purified polyclonal anti-DLX1
Specific Inquiry(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Antigen Detail | |
|---|---|
| Target | DLX1 |
| Description | Distal-less homeobox 1(DLX1) is a member of the DLX family of homeobox transcription factors, which is essential for the production of forebrain GABAergic interneurions during embryonic development. The DLX family of homeobox transcription factors (Dlx1, Dlx2, Dlx5 and Dlx6) is expressed in overlapping domains at different stages of cell differentiation in the subpallium and controls differentiation of GABAergic neurons. DLX1 possible has a role in craniofacial patterning and morphogenesis and involves in the early development of diencephalic subdivisions. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01260 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human DLX1 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-DLX1 Detection Antibody: Rabbit purified polyclonal anti-DLX1 |
| Specificity | Validated for detecting natural and recombinant human DLX1 |
| Research Area | Neurology process |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | DLX1 |
| Full Name | Distal-Less Homeobox 1 |
| Background | This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Alternative Names | Homeobox Protein DLX-1 |
| Gene ID | 1745 |
| Uniprot ID | P56177 |
| GeneCards | DLX1 |
| HGNC | 2914 |
| Ensembl | ENSG00000144355 |
| OMIM | 600029 |
| Involvement in Disease | Diseases associated with DLX1 include Dental Fluorosis and Witkop Syndrome. |
| Function | Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). |
| Related Pathways | Its related pathways are DNA Damage/Telomere Stress Induced Senescence and Regulation of nuclear SMAD2/3 signaling. |
For Research Use Only.
Related products Application
