Name: Human F10 ELISA Matched Antibody Pair Set [ABP-Q-04-154]
SKU: ABP-Q-04-154
Price: 1120 USD

Human F10 ELISA Matched Antibody Pair Set [ABP-Q-04-154] (CAT#: ABP-Q-04-154)

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Human F10 antibody pair set for ELISA useCapture Antibody: mouse anti-F10 monoclonal antibodyDetection Antibody: rabbit anti-F10 monoclonal antibody conjugated to HRP

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Type	Size	Price	Quantity
Antibody Pair Set-Package 1	5 × 96 tests	$1,120.00
Antibody Pair Set-Package 2	15 × 96 tests	$2,331.43

Datasheet

MSDS

Certificate of Analysis Lookup

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Lot Number

Antigen Detail
Target	F10
Description	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and central nervous system bleeding. Factor X is synthesized in the liver as a mature heterodimer formed from a single-chain precursor, and vitamin K is essential for its synthesis. Factor X is activated into factor Xa (FXa) by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Xase) and factor VII (with its cofactor, tissue factor in a complex known as extrinsic Xase) through cleaving the activation propeptide. As the first member of the final common pathway or thrombin pathway, FXa converts prothrombin to thrombin in the presence of factor Va, Ca2+, and phospholipid during blood clotting and cleaves prothrombin in two places (an arg-thr and then an arg-ile bond). This process is optimized when factor Xa is complexed with activated cofactor V in the prothrombinase complex. Inborn deficiency of factor X is very uncommon, and may present with epistaxis (nose bleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. Furthermore, factor X deficiency may be seen in amyloidosis, where factor X is adsorbed to the amyloid fibrils in the vasculature.
Species Reactivity	Human

Capture Antibody
Capture Clonality	Monoclonal
Host Species	Mouse
Clone	IV01914
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, pH 7.4
Application	ELISA

Detection Antibody
Det-Clonality	Monoclonal
Host Species	Rabbit
Conjugation	HRP
Clone	RD10165
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product Overview	Human F10 antibody pair set for ELISA use Capture Antibody: mouse anti-F10 monoclonal antibody Detection Antibody: rabbit anti-F10 monoclonal antibody conjugated to HRP
Specificity	Quantitative determination of Human F10
Range	5.47-350 pg/mL
Research Area	Blood
Application	ELISA
Application Notes	Optimal dilutions should be determined experimentally by the user.
Form	Lyophilized
Storage	Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size	1 Set
Sample Type	Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage Statement	Available for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene Symbol	F10
Full Name	Coagulation Factor X
Background	This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.
Alternative Names	Prothrombinase; FXA; Factor Xa
Gene ID	2159
Uniprot ID	P00742

For Research Use Only.

Human F10 ELISA Matched Antibody Pair Set [ABP-Q-04-154] (CAT#: ABP-Q-04-154)

Antigen Detail

Capture Antibody

Detection Antibody

General Product Property

Target Overview