Human GSC Matched Antibody Pair set for ELISA use
Capture Antibody: Mouse monoclonal anti-GSC
Detection Antibody: Mouse monoclonal anti-GSC, IgG2a Kappa
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Antigen Detail | |
|---|---|
| Target | GSC |
| Description | Homeobox protein goosecoid is a protein that in humans is encoded by the GSC gene. Due to its role as a transcription factor in cell migration during embryonic development, GSC has been looked into as a potential role-player in cancer development and metastasis, since embryonic development and cancer development share similar characteristics. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01581 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Biotin |
| Clone | RD10430 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human GSC Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-GSC Detection Antibody: Mouse monoclonal anti-GSC, IgG2a Kappa |
| Specificity | Validated for detecting natural and recombinant human GSC |
| Research Area | Transcription |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | GSC |
| Full Name | Goosecoid Homeobox |
| Background | This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. |
| Alternative Names | SAMS |
| Gene ID | 145258 |
| Uniprot ID | P56915 |
| HGNC | 4612 |
| Ensembl | ENSG00000133937 |
| OMIM | 138890 |
| Involvement in Disease | Diseases associated with GSC include Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities and Microtia. |
| Function | Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. |
| Related Pathways | Its related pathways are Regulation of retinoblastoma protein and Regulation of nuclear SMAD2/3 signaling. |
For Research Use Only.