Human GSTA4 Matched Antibody Pair set for ELISA use
Capture Antibody: Rabbit purified polyclonal anti-GSTA4
Detection Antibody: Mouse purified polyclonal anti-GSTA4
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Antigen Detail | |
|---|---|
| Target | GSTA4 |
| Description | Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis hence reduced expression of the GSTA4 enzyme may have pathophysiological consequences. The expression of this gene is decreased drastically among burn and trauma victims. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human GSTA4 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-GSTA4 Detection Antibody: Mouse purified polyclonal anti-GSTA4 |
| Specificity | Validated for detecting natural and recombinant human GSTA4 |
| Research Area | Drug metabolism |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | GSTA4 |
| Full Name | Glutathione S-Transferase Alpha 4 |
| Background | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008] |
| Alternative Names | Glutathione S-Transferase A4 |
| Gene ID | 2941 |
| Uniprot ID | O15217 |
| HGNC | 4629 |
| Ensembl | ENSG00000170899 |
| OMIM | 605450 |
| Involvement in Disease | Diseases associated with GSTA4 include Hepatocellular Carcinoma. |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). |
| Related Pathways | Its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. |
For Research Use Only.