Human Haptoglobin antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Biotin-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | Haptoglobin |
| Description | Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene.[5][6] In blood plasma, haptoglobin binds to free hemoglobin,[7] compared to hemopexin that binds to free heme,[8] released from erythrocytes with high affinity, and thereby inhibits its deleterious oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01352 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Immunogen | Recombinant Human Haptoglobin Protein. |
| Conjugation | Biotin |
| Clone | RD1023 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human Haptoglobin antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Biotin-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Human Haptoglobin. |
| Sensitivity | 122 pg/mL |
| Range | 312.5 pg/mL-20000 pg/mL |
| Research Area | Cardiovascular; Immunology |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | HP |
| Full Name | Haptoglobin |
| Background | Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene.[5][6] In blood plasma, haptoglobin binds to free hemoglobin,[7] compared to hemopexin that binds to free heme,[8] released from erythrocytes with high affinity, and thereby inhibits its deleterious oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). |
| Alternative Names | HP; BP; HP2ALPHA2; HPA1S; haptoglobin |
| Gene ID | 3240 |
| Uniprot ID | P00738 |
| GeneCards | HP |
| HGNC | 5141 |
| Ensembl | ENSG00000257017 |
| OMIM | 140100 |
| Involvement in Disease | Diseases associated with HP include Anhaptoglobinemia and Plasmodium Falciparum Malaria. |
| Function | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. |
| Related Pathways | Its related pathways are amb2 Integrin signaling and Binding and Uptake of Ligands by Scavenger Receptors. |
For Research Use Only.
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