Human HE4 ELISA Matched Antibody Pair Set [ABP-Q-04-384] (CAT#: ABP-Q-04-384)

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Human HE4 antibody pair set for ELISA use
Capture Antibody: mouse anti-Human HE4 monoclonal antibody
Detection Antibody: rabbit anti-Human HE4 monoclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $919.60
Antibody Pair Set-Package 2 15 × 96 tests $1,919.66
Datasheet
MSDS
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Lot Number

Antigen Detail
TargetHE4
DescriptionWAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP domains. WFDC2 / HE4 is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis. WFDC2 may be a component of the innate immune defences of the lung, nasal and oral cavities and suggest that WFDC2 functions in concert with related WAP domain containing proteins in epithelial host defence. WFDC2 re-expression in lung carcinomas may prove to be associated with tumour type and should be studied in further detail. Mammary gland expression of tammar WFDC2 during the course of lactation showed WFDC2 was elevated during pregnancy, reduced in early lactation and absent in mid-late lactation. WFDC2 / HE4 can undergo a complex series of alternative splicing events that can potentially yield five distinct WAP domain containing protein isoforms.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesMouse
CloneIV01512
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityMonoclonal
Host SpeciesRabbit
ConjugationHRP
CloneRD1058
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewHuman HE4 antibody pair set for ELISA use
Capture Antibody: mouse anti-Human HE4 monoclonal antibody
Detection Antibody: rabbit anti-Human HE4 monoclonal antibody conjugated to HRP
SpecificityQuantitative determination of Human HE4
Range15.625-1000 pg/mL
Research AreaProtease inhibitor
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolWFDC2
Full NameWAP four-disulfide core domain protein 2
BackgroundWAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4[5] (HE4) - is a protein that in humans is encoded by the WFDC2 gene.
Alternative NamesWFDC2; EDDM4; HE4; WAP5; dJ461P17.6; WAP four-disulfide core domain 2
Gene ID10406
Uniprot IDQ14508

For Research Use Only.

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