Human IL-21 antibody pair set for ELISA use
Capture Antibody: Mouse Monoclonal IgG1
Detection Antibody: Mouse Monoclonal IgG1
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Antigen Detail | |
|---|---|
| Target | IL-21 |
| Description | Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Production | Cell culture |
| Clone | IV01738 |
| Isotype | IgG1 |
| Purification | Protein G chromatography |
| Buffer | Prior to lyophilization: 0.25 ml PBS containing 125 mM trehalose |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Production | Cell culture |
| Conjugation | Biotin |
| Clone | RD102 |
| Isotype | IgG1 |
| Purification | Protein G-affinity chromatography |
| Buffer | Prior to lyophilization: 0.5 ml PBS, containing 1% BSA and 147 mM trehalose |
General Product Property | |
|---|---|
| Product Overview | Human IL-21 antibody pair set for ELISA use Capture Antibody: Mouse Monoclonal IgG1 Detection Antibody: Mouse Monoclonal IgG1 |
| Specificity | Validated for detecting natural and recombinant human IL-21 in supernatant |
| Sensitivity | 5 pg/ml |
| Research Area | Immunology |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | IL21 |
| Full Name | Interleukin 21 |
| Background | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Alternative Names | IL21; CVID11; IL-21; Za11; interleukin 21 |
| Gene ID | 59067 |
| Uniprot ID | Q9HBE4 |
| GeneCards | IL21 |
| HGNC | 6005 |
| Ensembl | ENSG00000138684 |
| OMIM | 605384 |
| Involvement in Disease | Diseases associated with IL21 include Immunodeficiency, Common Variable, 11 and Dacryoadenitis. |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Related Pathways | Its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and PEDF Induced Signaling. |
For Research Use Only.